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Tapentadol (Palexia, Palexia depot) er et sterkt opioid som finnes som tabletter og depottabletter til lindring av average til sterke akutte smerter.Populærkulturen romantiserer misbruget – eksperter efterlyser mere fokus på »livsfarligt stof«Den maksimale effekt kan manifestere sig i kind af afslappethed og en udpræget fileølelse af velbeh